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BioUnion filler is a bioactive glass particle that releases Zn 2+ in an acidic environment. In this study, the ion release, antibacterial, and physical properties of a glass ionomer cement (GIC) incorporating BioUnion filler (CA) were assessed in vitro. The concentration of Zn 2+ released from CA into acetic acid was higher than that released into water and its minimum inhibitory concentrations against six oral bacterial species. Moreover, the concentration of Zn 2+ -release was maintained during all the seven times it was exposed to acetic acid. Compared to a conventional cement and resin composite, CA significantly inhibited the growth of oral bacteria and hindered their adhesion on the material surface. Thus, our study outcomes show that the release of Zn 2+ from CA in the acidic environment does not affect its compressive strength.

Antibacterial effects and physical properties of a glass ionomer cement containing BioUnion filler with acidity-induced ability to release zinc ion