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The aim of this study was to investigate a failure criterion to predict flexural strengths of composite resins (CR) by three-dimensional finite element analysis (3D-FEA). Models of flexural strength for test specimens of CR and rods comprising a three-point loading were designed. Calculation of Young's moduli and Poisson's ratios of CR were conducted using a modified McGee-McCullough model. Using the experimental CR, flexural strengths were measured by three-point bending tests with crosshead speed 1.0 mm/min and compared with the values determined by in silico analysis. The flexural strengths of experimental CR calculated using the maximum principal strain significantly correlated with those obtained in silico amongst the four types of failure criteria applied. The in silico analytical model established in this study was found to be effective to predict the flexural strengths of CR incorporating various silica filler contents by maximum principal strain.

<i>In vitro</i>/<i>in silico</i> investigation of failure criteria to predict flexural strength of composite resins