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Bile acids exert anti-obesity and anti-hyperglycemic effects through a G protein-coupled receptor TGR5. In L cells located in the lower small intestine TGR5 activation stimulates secretion of a peptide hormone GLP-1 that enhances insulin sensitivity. In brown adipose tissues and skeletal muscles its activation results in an increase in energy expenditure, leading to antiobesity effects. Based on these findings, we searched for food factors that mimic bile acid functions, and identified a citrus limonoid nomilin as a powerful agonist for TGR5. Simulation

Extension of healthy life expectancy through activation of the bile acid receptor TGR5