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Literatures concerning the use of lactated Ringer's solution during surgery and for resuscitation of trauma or hemorrhagic shock had been accumulating extensively up until an appeal was raised for moderation in the use of buffered saline solution in patients (Moore, F. D. and Shire, S. T., 1967). Serious morbidity and even mortality were reported following the overenthusiastic use of large volumes of isotonic or hypotonic balanced saline solutions in pre-operative, operative and post-operative patients, as this was found to induce interstitial pulmonary edema (Frank, E. D. 1969; Fleming, W. H. and Bowen, J. C. 1972). Monafo, Wm. W. (1970) reported the successful use of hypertonic lactated Ringer's solution in burn patients for the sodium deficit induced by the injury. The hypotonicity of lactated Ringer's solution has not been discussed as one of the causes of interstitial pulmonary edema. It is a common concept that sodium lactate is ionized 100% in plasma of which the pH is over 7.0 units, as pK' of sodium lactate is 3.86 (a t

Depressed Ionization of Sodium Lactate in Hartmann's Solution may Cause Free Water Retention