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The effects of concomitant gastrointestinal drugs on the absorptivity of cefcapene-pivoxil hydrochloride (CFPN-PI) were examined in patients who were hospitalized due to infection and were to be treated with a gastrointestinal drug. CFPN-PI was orally administrated at a dose of 100mg after meals concomitant with a gastrointestinal drug. The urinary recovery rate of CFPN was determined from the urine collected for 12 hours after the first administration of CFPN-PI. In addition, the clinical efficacy and safety of CFPNPI was evaluated. The results were as follows:1. The mean urinary recovery rate of CFPN in 25 cases evaluable for the absorptivity of CFPN-PI was 24.7% (95% confidence interval: 21.0-28.3%). The mean urinary recovery rate of CFPN was 25 .6% in the famotidine group, 23.9% in the dried alminium hydrooxide gel group, and 25.2% in the teprenone group.Thus, there was no significant difference in the urinary recovery rate of CFPN among the concomitant drug groups (p-value: 0.9239).2. Clinical efficacy was judged as “excellent” in 4 cases, “good” in 16 cases, and “poor” in 2 cases, generating a clinical efficacy rate of 90.9%.3. The incidence of adverse drug reactions (ADRs) was 16.7%. All of the ADRs were slight in severity and were resolved without any treatment.Based on these results, it is suggested that the concomitant administration of the gastrointestinal drugs used in this study does not largely affect the absorptivity of CFPN-PI and the drug shows a sufficient antibacterial effect at the approved dose in such concomitant administration.

Effects of Concomitant Gastrointestinal Drugs on the Absorptivity (Urinary Recovery Rate) of Cefcapene-Pivoxil Hydrochloride (CFPN-PI)