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To evaluate the loading regimen of teicoplanin, the total concentration of teicoplanin (C24) and free teicoplanin concentrations (C24free) in serum were measured 24 hrs after the start of therapy. Thirty-eight points of blood samples from 35 patients were obtained after the intravenous loading of teicoplanin (200 or 400 mg per dose, every 12 hrs) . Twelve patients received 200 mg of teicoplanin twice a day with a loading time interval of 12 hrs (400 mg/day group) , and others received 400 mg twice a day, every 12 hrs (800 mg/day group). The acquired C24 was 4.4•}1.7ƒÊg/mL (mean•}SD) in the 400 mg/day

The Evaluation of Serum Total and Free Teicoplanin Concentrations after Intravenous Loading