English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We investigated adenylate cyclaserelated hormone actions induced by colforsin daropate hydrochloride (Adehl® Inj.: AD) injected by intravenous administration at 0.5 μg/kg/min for 3 hrs in 9 male healthy volunteers (age;21-32 y), compared with control administration of physiologic saline. Adenylate cyclaserelated parameters on serum chemistry, urine test and hormone secretion levels were measured at preadministration and, 1 and 3 hours after administration. [Statistics] As for statistic analysis to determine agent effects, we adopted both 95% confidence interval test (95%CI-test) and paired t-test. By 95%CI-test, we detected the discrepancy between 95% CI of each observed data and its standard value range, and by paired t-test we detected data changes between preadministration and post-administration. [Results] Adrenaline, insulin, ACTH, cortisol, NEFA, glycerol, and FT3, increased among glucose metabolism-or fat metabolism-related parameters. Concerning bone/Ca metabolism-related parameters, serum Ca, ALP, totalprotein, albumin, and serum cAMP increased while serum P and PTH-I decreased. And serum K decreased in water absorption-related parameters of kidney function. In sex hormones, FSH and testosterone in-creased. In the other hormones, noradrenaline and plasma renin activity increased. However, changes of all the detected parameters were transient within their normal ranges or standard limits, and were graded in minute or slight (plasma rennin activity only). [Discussion & Conclusion] We concluded that almost all the changes of these observed parameters were attributed to AD hemodynamic effects such as chronotropic action, inotropic action and vasodilating action, which were linked to hormonal secretion level changes (ACTH increase, adrenaline increase, noradrenaline increase) by way of cardiovascular homeostasismechanism or auto-regulation system. Concerning the slight increase of serum cAMP, it had no linkage to any hormonal secretions. The PTH-like action of AD such as PTH-I decrease reported in the precedent animal study was also observed.

Effects of Colforsin Daropate Hydrochloride (Adehl Inj.), Anti-Acute Heart Failure Agent, on Adenylate Cyclase-Related Hormone Actions