English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Objective : To assess the efficacy of antihypertensive drugs, the time structure and autonomic nervous activity were calculated from 24-hour systolic blood pressure (24SBP) data in hypertensive patients. Design and Method : Fifty-six patients with hypertension were treated with cilnidipine (10 mg once a day) or nifedipine-L (Nd-L, 20 mg twice a day) for 4.9•}2.3 months. The 24SBP and electrocardiogram were recorded every 30 min before and after drug administration. The periodic structure of 24SBP was analyzed by the maximum entropy method (MEM) . The fluctuation index (FI) of 24SBP given by the standard deviation of the differences from observed to best fittied SBP values was newly introduced to evaluate the 24-hour variability of SBP. The maximum speed of rise in SBP (maxƒ¢SBP) and low frequency (LF) /high frequency(HF) power ratio from the heart rate variability in the 3 hrs after rise were also measured. Results : The responders on anti-hypertensive therapy with cilnidipine (n=16) and Nd-L (n=17) were analyzed. The circadian rhythm during cilnidipine seemed to be normal. After the fall in BP, FI was decreased in cilnidipine from 1.09 to 0.94, but FI was increased in Nd-L responders from 0.91 to 0.98. The maxƒ¢SBP was reduced in both cilnidipine and Nd-L responders. LF/HF became significantly lower in cilnidipine (2.5 to 2.0), but it rose in Nd-L responders from 2.2 to 2.8. Conclusions : The FI can be considered as an index to assess the baro-reflex sensitivity throughout the day. The change in the time structure of circadian rhythm during the treatment is thought to be a means to evaluate the efficacy of anti-hypertensive therapy.

Actions of Calcium Antagonists on Circadian Systolic Blood Pressure Rhythm and Autonomic Function in Hypertensive Patients