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The pharmacokinetic parameters, extracted from the Bayer group data pool, were compared between the Japanese and Caucasian healthy volunteers who received nifedipine or nisoldipine. Comparisons of the parameters were made respectively for each drug with the identical formulations between the two races. Cmax, AUC and t1/2 (and CL for nifedipine) were used as comparative parameters, and compared in geometric means and medians for nifedipine and ranges of mean values in each pharmacokinetic study for nisoldipine. However, as the administered drug dosage and the subject's body structure differed between the two races, Cmax,norm and AUCnorm (multiplied by the body weight and divided by the drug dosage) were used as comparative parameters for Cmax and AUC.

Investigation on the Interethnic Differences in the Pharmacokinetics of Nifedipine and Nisoldipine.