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Ambulatory blood pressure (BP) was obtained before and 2 months after the initiation of atenolol therapy in subjects with mild essential hypertension to determine whether the administration of atenolol, a beta adrenoreceptor blocking agent , modifies the circadian pattern of blood pressure. BP was measured by a non-invasive automatic device with a 15-min interval during a 24-hr period, and was analyzed by fitting of power-normal transformation model (PNT model). The circadian pattern of systolic BP in 4 patients out of 6 and diastolic BP in 2 out 6 were modified and the amplitude of systolic BP was reduced with a prolonged atenolol therapy. These findings indicate that the circadian pattern of BP is modified by chronic atenolol therapy, which is caused by the suppression of the elevation of BP during the daytime .

Influence of beta-adrenergic blocking agent on the circadian rhythm of blood pressure in patients with essential hypertension.