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The difference in bioavailability of nicorandil, a newly developed antianginal agent, before and after eating was studied in 10 healthy male volunteers. The phar macokinetic parameters after single oral administration of nicorandil (10 mg) were calculated by an automated pharmacokinetic analysis system according to a one-compartment open model. According to a statistical analysis, the values of Cmax, Tmax, [AUC] ∞0, Ke, and t1/2 in the bioavailability of nicorandil were not significantly affected by the ingestion of a meal, but that of Ka (apparent first order absorption constant) was significantly lowered by the ingestion.

Bioavailability study of nicorandil before and after meals.