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the hemoglobin to the right but did not affect the 2, 3-DPG contents on incubation of blood samples for 2 to 4 hours with the drug. In vivo administration of dilazep (300 mg/day for one week), however, produced a significant shift of the curve to the left. This leftward shift was accompanied with a tendency for contents of 2, 3-DPG to decrease without a significant changes in HbAic levels. There were no changes observed in P50, 2, 3-DPG and HbAlc levels with a lower dosage of dilazep (150 mg/day for one week). These findings suggested that the increased oxygen binding to hemoglobin induced

Effects of Dilazep Dihydrochloride on the Oxygen Dissociation Curve of the Hemoglobin