English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

The kinetic resolution of piperazine-2-carboxylic acid was studied as its N-4and N-1-Bocpiperazine-2-carboxylic acid methyl esters, rac-1 and -2, respectively. Lipase A from Candida antarctica (CAL-A) catalyzed highly enantioselective (E>200 for rac-1 and 200 for rac-2) Nacylation of both compounds with 2,2,2-trifluoroethyl butanoate in TBME. Aldehyde-based dynamic kinetic resolution of rac-1 with vinyl butanoate in acetonitrile gave up to 75% product yield with S-absolute configuration in 48 hours. The present results together with literature data suggest that CAL-A –catalyzed N-acylation is enhanced in terms of reaction rate or enantioselectivity when an electron rich structure, such as carboxylic ester or aromatic ring, is attached to the asymmetric center next to the secondary ring nitrogen.

arkivoc

Advances in the kinetic and dynamic kinetic resolution of piperazine-2-carboxylic acid derivatives with Candida antarctica lipase A; structural requirements for enantioselective N-acylation