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Reaction of 2-arylhydrazono-1-phenylethanones 2a-c with formaldehyde either in presence of montmorillonite K10 or by simply stirring in methanol and TEA leads to selective synthesis of 2arylhydrazono-3-hydroxy-1-phenylpropan-1-one derivatives 3a-c in high yield. Heating 1a with N-phenylmaleimide in DPE/DABCO using microwave irradiation for 5 minutes at 200 C results in a 73% yield of pyrrolo[3,4-c]pyridazine 8. Compounds 2a-c react with benzylidenemalononitriles 9a or ethyl 2-cyanocinnamate 9b in refluxing ethanol and piperidine or -chitosan to yield new pyridazine derivatives 10a-f which are converted into pyridazinones 11a-c upon reflux in acetic/hydrochloric acids mixture.

Improved synthesis of 2-arylhydrazono-3-hydroxy-1-propanones and their utility in efficient synthesis of pyridazine derivatives