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The butanol extract of the Mediterranean sponge Axinella verrucosa was fractionated via a bioactivity-guided procedure based on an antibacterial assay. This approach led to the isolation of the novel alkaloid debromo-carteramine A 2 co-occurring with known hymenidin 1, the main antibacterial agent of the extract, and related inactive carteramine A 3.

Structure of debromo-carteramine A, a novel bromopyrrole alkaloid from the Mediterranean sponge Axinella verrucosa