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An environmentally benign, efficient and facile route is developed for the synthesis of novel spiro[indoline-3,2'-thiazolo[5,4-e]pyrimido[1,2-a]pyrimidine] derivatives. The benzylidene derivatives of spiro[indoline-thiazolidinones] 6 containing an α,β-unsaturated ketonic function [CH=CH-CO-] have been used as a component of Michael addition with an equimolar amount of 2-aminopyrimidine 7 to give a series of novel spiroindole derivatives 9 in a single step using montmorillonite KSF as inorganic solid support with few drops of DMF. In comparison to conventional synthesis involving tedious multistep procedures, the present method indicates operational simplicity, shorter reaction time and higher yields which can prove this procedure as a useful alternative for the synthesis of novel spiro heterocycles.

New strategy for the synthesis of novel spiro[indoline-3,2'-thiazolo[5,4-e]pyrimido[1,2-a]pyrimidine] derivatives