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A new series of 2-amino-3-cyano-4-tetrazoloquinolinylpyridine derivatives has been synthesized by the one-pot cyclocondensation reaction of a tetrazolo[1,5-a]quinoline-4-carbaldehyde, malononitrile, a heterocyclic/aromatic methyl ketone and ammonium acetate. All the synthesized compounds were subjected to in vitro antimicrobial screening against a panel of pathogenic strains of bacteria and fungi. Some of the compounds were found to be equipotent or more potent than commercial antibiotics as evident from the results.

An efficient one-pot synthesis and in vitro antimicrobial activity of new pyridine derivatives bearing the tetrazoloquinoline nucleus