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A simple and convenient protocol for the synthesis of β-acetamido ketones has been described by one-pot three-component reaction of aromatic aldehydes and enolizable ketones or β-keto esters and acetonitrile using cerium(IV) sulfate as a catalyst. The present methodology offers several advantages such as excellent yields, non hazardous reaction condition and short reaction times.

Cerium(IV) sulfate catalyzed simple and convenient synthesis of β-acetamidocarbonyl compounds