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The acid dissociation constants (Ka) of eight novel biologically active benzothiazole Schiff bases were determined by UV-vis spectroscopic technique at 25 ± 0.1 °C. The calculated acidity constants, pKa values, were evaluated in structure elucidation and protonation - deprotonation mechanisms. The prototropic tautomerism was also studied.

Determination and evaluation of acid dissociation constants of some novel benzothiazole Schiff bases and their reduced analogs by spectroscopy