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Bioactivity directed fractionation of the chloroform extract of the root bark of Maytenus senegalensis resulted in the isolation and characterization of the quinonemethide triterpene, (20α)-3-hydroxy-2-oxo-24-nor-friedela-1(10),3,5,7-tetraen-carboxylic acid-(29)-methylester (pristimerin). The structure was elucidated by spectroscopic techniques. The in vitro antiplasmodial activity of the isolated compound against chloroquine-resistant strain (Dd2) of Plasmodium falciparum was IC50 = 0.5µg/ml and its in vitro antileishmanial activity performed on promostigotes of Leishmania major was IC50 = 6.8 ± 0.8 µg/ml while the cytotoxicity on lymphocyte proliferation model was detected at IC50= 6.8 ± 0.8 µg/ml.

Isolation and characterization of pristimerin as the antiplasmodial and antileishmanial agent of Maytenus senegalensis (Lam.) Exell.