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Methyl 2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoatesbearing an amino acid ester residue were prepared by a novelthree step sequential reaction of N-(2-cyanophenyl)benzimidoylisothioyanate with amino acid methyl ester hydrochlorides. Somechemoselective reactions of methyl2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoates with alkylhalides were studied.

Synthesis and reactions of methyl 2-[3-(2-phenylquinazolin-4-yl)thioureido]alkanoates