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Synthesis of meso-tetrakis (2, 10-dioxo-2H, 10H-pyrano[2,3-f] chromene-9-yl) porphyrins are synthesized directly by reaction of pyrrole with substituted 4-methyl-2,10-dioxo-2H, 10Hpyrano[2,3-f]chromene-9-carbaldehydes in dichloromethane / acid media. The aldehyde’s molar ratio was controlled to optimize the synthesis and purification of the desired porphyrins. This new series of porphyrins was characterized by TLC, Mass Spectrometry (FAB mass), H NMR, UV and IR

Synthesis and biological activity of meso-tetrakis (2,10-dioxo-2H, 10H-pyrano [2,3-f] chromene-9-yl) porphyrins