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The synthesis of two contaminants of Loratadine, generated when the product is formulated as a syrup, is described. The products, identified as 2and 4-hydroxymethyl derivatives of the starting compounds, are obtained by the corresponding substitution of the pyridine moiety of Loratadine.

Synthesis of 2- and 4-hydroxymethyl Loratadine, usual impurities in Loratadine syrup formulations