Open AccessSynthesis and characterization of new 2-(alkylamino)acetamides
Author(s) -
Teresa Mancilla,
L.S. Zamudio-Rivera,
Lourdes Carrillo,
H.I. Beltrán,
Norberto Farfán
Publication year - 2003
Publication title -
arkivoc
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 58
eISSN - 1551-7012
pISSN - 1551-7004
DOI - 10.3998/ark.5550190.0004.b05
Subject(s) - chemistry , acetamide , two dimensional nuclear magnetic resonance spectroscopy , mass spectrometry , single crystal , crystallography , characterization (materials science) , carbon 13 nmr , stereochemistry , computational chemistry , organic chemistry , nanotechnology , chromatography , materials science
Seven new 2-(alkylamino)acetamides have been synthesized and characterized by 1 H, 13 C NMR, NOESY experiments, infrared and mass spectrometry. The structure of 2(diphenylmethylamino)acetamide 3b was further established by a single crystal x-ray diffraction study. The NMR study of the transformation of several 2-(alkylamino)acetamides to their corresponding morpholin-2-ones shows that these species are thermodynamically favored through preferred conformations as determined by theoretical calculations of 3h.
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