Open AccessTotal synthesis of hydroxymethyl isonucleosides as potential antiviral agents
Author(s) -
Vasu Nair,
ByoungKwon Chun
Publication year - 2003
Publication title -
arkivoc
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.21
H-Index - 58
eISSN - 1551-7012
pISSN - 1551-7004
DOI - 10.3998/ark.5550190.0004.102
Subject(s) - chemistry , hydroxymethyl , furan , nucleobase , total synthesis , stereospecificity , alkene , combinatorial chemistry , mitsunobu reaction , stereochemistry , organic chemistry , catalysis , biochemistry , dna
Hydroxymethyl isodideoxynucleosides, designed as potential antiviral agents, have been synthesized through development of a multi-step procedure starting from furan and cyanovinyl acetate. Key steps in the synthesis include a Diels-Alder reaction, oxidative cleavage of alkene, a Mitsunobu reaction, stereospecific introduction of amino group and nucleobase construction.
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