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6-Cyclopropylethynyl-6-trifluoromethyl dihydro-2-oxopurines have been prepared with completely regioselective addition of trimethyl(trifluoromethyl)silane and cyclopropylethynylmagnesium bromide to 1,9-dialkylated 2-oxopurines as key-steps. The target compounds are structurally related to the Non-Nucleoside reverse transcriptase inhibitors Efavirenz and DPC 961.

Synthesis of 2-oxopurine adducts with structural resemblance to Efavirenz and DPC 961 as potential NNRT-inhibitors