English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

A three step synthesis leading to the title compound in good overall yield is described. The bicyclo(3.2.0)heptane framework was formed with good stereocontrol by (π2s + π2a) thermal cycloaddition of the readily available phthalimidoketene with cyclopentadiene. The racemic bicyclic β-amino alcohol 4 was conveniently obtained by mild cleavage of the phthalimide protecting group, in 60 % yield. Resolution with L-aspartic acid allowed access to the (-)- enantiomer of the required β-amino alcohol ligand 4 in 34 % yield and 98 % enantiomeric excess.

Synthesis of enantiopure 7-aminobicyclo[3.2.0]hept-2-en-6-ol; a potential N-O chelating ligand for enantioselective catalysis