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The high dietary intake of n-6 fatty acids in relation to n-3 fatty acids generates health disorders, such as cardiovascular diseases, inflammatory diseases and other chronic diseases. The consumption of fish, which is rich in n-3 fatty acids, is low in Latin America and it is necessary to seek other alternatives, such as chia oil (CO) or rosa mosqueta oil (RMO), which are rich in α-linolenic acid (ALA), the precursor of the n -3 fatty acids, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). This study evaluates the hepatic bioconversion of ALA to EPA and DHA and the damage to the liver (histology and transaminase) in Sprague- Dawley rats fed different vegetable oils. Four experimental groups (n = 9 animals each group) were fed the following dietary supplements for 21 days: a) sunflower oil (SFO), b) RMO, c) CO d) olive oil with fish oil added (EPA and DHA) (OO/FO). RMO and CO increased the hepatic levels of ALA, EPA and DHA and decreased the n-6/n-3 ratio compared to SFO (p < 0.05) without changes in the parameters of liver damage. It is concluded that CO and RMO may be nutritional alternatives for providing ALA for its bioconversion to EPA and DHA.  El elevado aporte en la dieta de ácidos grasos omega- 6, en relación a los ácidos grasos omega-3, genera alteraciones de la salud cardiovascular, inflamación y otras patologías crónicas no transmisibles. Por otro lado, el pescado rico en ácidos grasos omega-3 es de bajo consumo en Latinoamérica, siendo necesario buscar otras alternativas de aporte de ácidos grasos omega-3, como lo son el aceite de chía (CO) o el de rosa mosqueta (RMO), ricos en ácido α-linolénico (ALA), que es el precursor de los ácidos grasos omega-3, eicosapentaenoico (EPA) y docosahexaenoico (DHA). Este trabajo evaluó en forma preliminar la bioconversión hepática del ALA en EPA y DHA y el daño hepático (histología y transaminasas) en ratas Sprague-Dawley alimentadas con diferentes aceites vegetales. Se conformaron cuatro grupos experimentales (n = 9 animales por grupo) que recibieron durante 21 días: a) aceite de girasol (SFO); b) RMO, c) CO y d) aceite de oliva adicionado de aceite de pescado (EPA + DHA) (OO/FO). RMO y CO aumentaron los niveles hepáticos de ALA, EPA y DHA y disminuyeron la razón n- 6/n-3 respecto a SFO (p < 0,05), sin cambios en parámetros de daño hepático. Se concluye que CO y RMO pueden ser una alternativa nutricional de aporte de ALA para su bioconversión en EPA y DHA

grasas y aceites

Evaluation of the hepatic bioconversion of α-linolenic acid (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in rats fed with oils from chia (<i>Salvia hispánica</i>) or rosa mosqueta (<i>Rosa rubiginosa</i>)

Evaluation of the hepatic bioconversion of α-linolenic acid (ALA) to eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in rats fed with oils from chia (Salvia hispánica) or rosa mosqueta (Rosa rubiginosa)