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DHA has been established. We propose that DHAcontaininglysophosphatidylcholine (DHA-LPC), obtainedfrom DHA-rich eggs may be a suitable form of DHA andcholine (the precursor of acetylcholine) supplementation.We evaluated the effectiveness of DHA-LPC to increaseDHA and acetylcholine concentration in the brain of pupsborn from female rats supplemented with DHA-LPC beforeand during pregnancy. We also evaluated the effect of DHAsupplementation on learning and memory capabilities of pupsthrough the Skinner test for operant conditioning. FemaleWistar rats received 40-day supplementation of DHA-LPC (8mg DHA/kg b.w/daily.), before and during pregnancy. Afterdelivery, plasma, erythrocyte, liver, and adipose tissue DHAand plasma choline were analyzed. Brains from 60 day-oldpups separated into frontal cortex, cerebellum, striatum,hippocampus, and occipital cortex, were assessed for DHA,acetylcholine, and acetylcholine transferase (CAT) activity.Pups were subjected to the Skinner box test. DHA-LPCsupplementation produces higher choline and liver DHAcontents in the mother’s plasma and increases the pups’DHA and acetylcholine in the cerebellum and hippocampus.CAT was not modified by supplementation. The Skinner testshows that pups born from DHA-LPC supplemented mothersexhibit better scores of learning and memory than thecontrols. Conclusion: DHA-LPC may be an adequate form forDHA supplementation during the perinatal period.This research was partially supported byFONDECYT (project 1050515) and INNOVACORFO

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Supplementing female rats with DHA-lysophosphatidylcholine increases docosahexaenoic acid and acetylcholine contents in the brain and improves the memory and learning capabilities of the pups.