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Hyperkalemic periodic paralysis (hyperKPP) is a muscle sodium-ion channelopathy characterized by recurrent paralytic attacks. A proportion of affected individuals develop fixed or chronic progressive weakness that results in significant disability. However, little is known about the pathology of hyperKPP-induced fixed weakness, including the pattern of muscle involvement. The aim of this study was to characterize the patterns of muscle involvement in hyperKPP by whole-body magnetic resonance imaging (MRI).

journal of clinical neurology/the journal of clinical neurology

Whole-Body Muscle MRI in Patients with Hyperkalemic Periodic Paralysis Carrying the<i>SCN4A</i>Mutation T704M: Evidence for Chronic Progressive Myopathy with Selective Muscle Involvement

Whole-Body Muscle MRI in Patients with Hyperkalemic Periodic Paralysis Carrying theSCN4AMutation T704M: Evidence for Chronic Progressive Myopathy with Selective Muscle Involvement