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Endoscopic submucosal dissection (ESD) invented in Japan, plays an important role in the treatment of early gastrointestinal cancer (EGC) and dysplasia. Endoscopic procedures are now widely spreading around the world. ESD has the advantage that en bloc resection as well as pathological view can be achieved when compared with conventional endoscopic mucosal resection (1). Thanks to the Japanese innovators, these procedures have benefited a great number of patients by improving their life quality. Though ESD has become the standard treatment in Japan for EGCs, there is still much to be developed for the rest of the world. Therefore, the journal Annals of Translational Medicine has published a special issue dedicated to “Endoscopic therapy in the Japanese state and perspective”. This issue is guest

Highlight of Endoscopic procedures developed in Japan.