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Dendritic cells(DC)are essential antigen-presenting cells(APC)with a unique capacity to initiate an immune response. We described the in vitro generation of rabbit monocyte-derived DC (Mo-DC)in the presence of granulocyte macrophage-colony stimulating factor and interleukin-4. Autologous DC,which had phagocytosed apoptotic Ra-1 cells,acted as an APC for cellular response following their injection into human T lymphotropic virus type I (HTLV-I)-infected rabbits. PKH-26 labeled DC preferentially homed to the T cell area of the draining lymph node following s.c. injection,whereas i.v.-injected DC accumulated in the spleen. We demonstrated that rabbit Mo-DC functioned as potent APC in vivo and that the route of DC administration was inconsequential for cytotoxic T lymphocytes response. Although Mo-DC generated from patients with adult T-cell leukemia/lymphoma (ATLL)show a functional impairment,this study provides evidence that a new,supporting immunotherapy using the donor’ s DC generates a more efficient anti-HTLV-I infected cell/ATLL cell immune response following allogeneic stem cell transplantation.

Generation of Functional Monocyte-Derived Dendritic Cells from HTLV-I Infected Rabbits: Therapeutic Approach Using a Dendritic Cell Vaccine