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Self-arrangement of DNA based structures on clean mica and modied Si surfaces is investigated by means of scanningprobe microscope (SPM) and spectroscopic ellipsometry (SE) method. DNA strands are deposited from a colloidal solutionon solid surfaces at room temperature. Surfaces of solid substrates and biomolecular structures are additionally modied byAg nanoparticles. The self-arranged surface structures are visualized by SPM. The effect of the multicomponent structureson the optical response of complex hybrid structures is studied. Changes in the optical response of the hybrid samples arerelated to the contributions of self-assembled DNA-based structures and Ag nanoparticles on the Si surfaces. Binding of Agnanoparticles to the DNA strands and formation of well-ordered structures on the surfaces with DNA are discussed.

Scanning probe microscopic and optical detection of DNA integration within multicomponent structures on Si surfaces