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A new antibody associated with squamous cell carcinoma, YM-Antibody, containing components of pI 5.95-6.10 fractions, was produced from cell cultures of squamous cell carcinoma of the larynx. To elucidate the immunological characteristics of YM-Antibody, it and 6 other commercially available antibodies were investigated immunohistochemically by applying them to squamous cell carcinomas and non-malignant tissues obtained from various regions of the head and neck. The results showed high positivity of YM-Antibody (85.0%) on squamous cell carcinoma and extremely low false-positivity (10.5%) on non-malignant tissue. These findings suggest that the diagnostic efficacy of this YM-Antibody is 76.2%, while that of the other antibodies was less than 50%. The YM-Antibody will be useful as a diagnostic tool for squamous cell carcinoma of the head and neck.

IMMUNOHISTOCHEMICAL STUDY OF A NEW SQUAMOUS CELL CARCINOMA-ASSOCIATED ANTIBODY (YM-ANTIBODY) PREPARED FROM CULTURED LARYNGEAL CARCINOMA CELLS