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Platelet-activating factor (PAF) is released in vitro by the reaction of antigen and IgE antibody on basophilic cells. In order to clarify that PAF was released in vivo during nasal allergic response, we measured PAF activities in nasal lavage fluids from both 10 patients with pollinosis and ovalbumin (OA)-sensitized guinea pigs before and after topical antigenic challenge. PAF activities were measured by their aggregating ability of washed rabbit platelets. The levels of lyso-PAF were determined after acetylation of lyso-form into the biologically active form of PAF. PAF or Lyso-PAF activities were detected in the nasal lavage fluids soon after the topical antigenic challenge in 7 patients. They were also found during late phase of between 3 and 8 hours after the challenge in 8 patients. In sensitized animals, PAF activities in the nasal lavage fluids significantly increased soon after topical antigenic stimulations. These data suggested that PAF was released during both early and late-phase nasal allergic reactions and might account for pathogenesis of allergic rhinitis.

Detection of platelet-activating factor in nasal lavage fluid from patients with pollinosis and experimental animals with nasal allergy.