Open AccessNutrient-Induced Stimulation of Protein Synthesis in Mouse Skeletal Muscle Is Limited by the mTORC1 Repressor REDD1
Author(s) -
Bradley S. Gordon,
David L. Williamson,
Charles H. Lang,
Leonard S. Jefferson,
Scot R. Kimball
Publication year - 2015
Publication title -
journal of nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.463
H-Index - 265
eISSN - 1541-6100
pISSN - 0022-3166
DOI - 10.3945/jn.114.207621
Subject(s) - mtorc1 , phosphorylation , stimulation , repressor , medicine , pi3k/akt/mtor pathway , endocrinology , chemistry , biology , signal transduction , gene , gene expression , biochemistry , protein kinase b
In skeletal muscle, the nutrient-induced stimulation of protein synthesis requires signaling through the mechanistic target of rapamycin complex 1 (mTORC1). Expression of the repressor of mTORC1 signaling, regulated in development and DNA damage 1 (REDD1), is elevated in muscle during various atrophic conditions and diminished under hypertrophic conditions. The question arises as to what extent REDD1 limits the nutrient-induced stimulation of protein synthesis.
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