Open AccessEnergy intake and energy expenditure among children with polymorphisms of the melanocortin-3 receptor
Author(s) -
David M. Savastano,
Marian TanofskyKraff,
Joan C. Han,
Ning Cong,
Rachael Sorg,
Caroline A. Roza,
Laura E. Wolkoff,
Kavitha Anandalingam,
Kyra JeffersonGeorge,
Roberto Figueroa,
Ethan L. Sanford,
Sheila M. Brady,
Merel Kozlosky,
Dale A. Schoeller,
Jack A. Yanovski
Publication year - 2009
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.2009.27537
Subject(s) - energy balance , obesity , body mass index , endocrinology , resting energy expenditure , medicine , doubly labeled water , melanocortin , biology , basal metabolic rate , energy expenditure , receptor , ecology
Homozygosity for 2 protein-altering polymorphisms in the melanocortin-3 receptor gene (MC3R) coding sequence, C17A and G241A, has been reported to be associated with an obesity phenotype in children, yet how these polymorphisms affect energy homeostasis is unknown. Association between adult body weight and +2138InsCAGACC, another variant in the 3' untranslated region of MC3R, has also been described.
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