Open AccessSubstrate product ratios of enzymes in the kynurenine pathway measured in plasma as indicators of functional vitamin B-6 status
Author(s) -
Arve Ulvik,
Despoina Theofylaktopoulou,
Øivind Midttun,
Ottar Nygård,
Simone J. P. M. Eussen,
Per Magne Ueland
Publication year - 2013
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.113.064998
Subject(s) - kynurenine , xanthurenic acid , pyridoxal , transaminase , kynurenine pathway , chemistry , medicine , endocrinology , pyridoxal phosphate , pyridoxine hydrochloride , tryptophan , kynurenic acid , anthranilic acid , biochemistry , enzyme , pyridoxine , biology , amino acid , cofactor
Tryptophan metabolism through the kynurenine pathway includes 2 vitamin B-6 [pyridoxal 5'-phosphate (PLP)]-dependent enzymes. We recently showed that plasma 3-hydroxykynurenine (HK) was elevated at low PLP concentrations.
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