Open AccessNuclear transcription factor κ B activation and protein turnover adaptations in skeletal muscle of patients with progressive stages of lung cancer cachexia
Author(s) -
Celine M. Op den Kamp,
Ramon Langen,
Frank J. M. Snepvangers,
Chiel C. de Theije,
Johanna M Schellekens,
Fabian Laugs,
AnneMarie C. Dingemans,
Annemie Schols
Publication year - 2013
Publication title -
american journal of clinical nutrition
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.608
H-Index - 336
eISSN - 1938-3207
pISSN - 0002-9165
DOI - 10.3945/ajcn.113.058388
Subject(s) - cachexia , endocrinology , protein kinase b , medicine , muscle atrophy , skeletal muscle , biology , myostatin , pi3k/akt/mtor pathway , autophagy , inflammation , wasting , cancer research , phosphorylation , signal transduction , cancer , microbiology and biotechnology , biochemistry , apoptosis
Experimental models of cancer cachexia have indicated that systemic inflammation induces muscle-protein breakdown and wasting via muscular nuclear transcription factor κB (NF-κB) activation. This process may limit the efficacy of nutritional intervention.
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