TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention | Zendy

Josiemer Mattei | Zendy; Qibin Qi | Zendy; Frank B. Hu | Zendy; Frank M. Sacks | Zendy; Lu Qi | Zendy

Open Access

TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention

Author(s) -

Josiemer Mattei,

Qibin Qi,

Frank B. Hu,

Frank M. Sacks,

Lu Qi

Publication year - 2012

Publication title -

american journal of clinical nutrition

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.608

H-Index - 336

eISSN - 1938-3207

pISSN - 0002-9165

DOI - 10.3945/ajcn.112.038125

Subject(s) - composition (language) , weight loss , body weight , genetic variants , obesity , food intake , biology , food science , medicine , endocrinology , genetics , genotype , gene , philosophy , linguistics

TCF7L2 gene variants have been associated with increased risk of type 2 diabetes and higher adiposity. Observational studies and short-term trials have suggested that macronutrients may modify these effects. However, to our knowledge, this has yet to be verified in long-term interventions.

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