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The source of Kami-shoyo-san varies in the literature. The current formula contains ten kinds of medicine. Only Shoyo-san is described in "He ii ju fang". In "Nil ke cuo yao" and "Nei ke zhai yao", a formula containing eight medicines without ginger and mentha was descrided. It was in "Wan bing hui chun" after Xue Ji that a formula containing ten kinds of medicine was first specified. The source of its combination with Shimotsu-to also varies in the literature. There is no mention of this combination in the "He ji ju fang". In the "Nei ke zhai yao", there is a case where eight-medicine formulations in combination with Shimotsu-to were used. Although ten-medicine plus Shimotsu-to are, in fact, described in "Futsugo-yakushitsu-houkan-kuketsu", my investigation found that such a combination formula was used for general pruritus in "Ryo-chikeiken-hikki" about 90 years previously. I believe that if the process of establishing a formula is complicated, as in the case of Kami-shoyo-san, every activity contributing to each step in establishing the formula is generally included as a part of its source and that any activity, in which a combination of formulae was very effective, is regarded, in principle, as its source.

The Sources of Kampo Formulae, Kami-shoyo-san and its Combination with Shimotsu-to.