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Objectives : The aim of this narrative review of the literature was to synthesize and comment the mechanisms of action of avocado/soybean unsaponifiable mixture (ASU-E, Piascledine®300) on articular tissues involved in the OA pathogenesis. Materials and methods: The search was performed in Pubmed and Scopus between January 1981 and December 2016. Keywords used were—any field—(Cartilage OR Bone OR Synovium) AND Avocado AND Soybean. 32 articles out-off 35 found have been considered. The review has included eleven in vitro and animal studies investigating Avocado Soybean Unsaponifiables (ASU) from Laboratoires Expanscience (Piascledine®300) used separately or in combination. Only research articles published in English and French have been taken into account. Results: ASU-E stimulated proteoglycans synthesis in chondrocytes cultures and counteracted the effects of IL-1 on metalloproteases and inflammatory mediators. Some of these effects were associated with inhibition of NF-kB nuclear translocation and stimulation of TGF-synthesis. ASU-E also positively modulated the altered phenotype of OA subchondral bone osteoblasts and reduced the production of collagenases by synovial cells. Conclusions: ASU-E has positive effects on the metabolic changes of synovium, subchondral bone and cartilage which are the main tissues involved in the pathophysiology of OA. These findings contribute to explain the beneficial effects of ASU-E in clinical trials.

aims medical science

Avocado/Soybean Unsaponifiables (Piacledine®300) show beneficial effect on the metabolism of osteoarthritic cartilage, synovium and subchondral bone: An overview of the mechanisms