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57 6 INTRODUCTION  59 MATERIALS & METHODS 61 RESULTS  66 DISCUSSION 82 CHAPTER II GFAP-expressing cells are multipotent progenitors with limited self-renewal potential in the adult spinal cord  88 ABSTRACT  88 INTRODUCTION  89 MATERIALS & METHODS 91 RESULTS  95 DISCUSSION 112 CHAPTER III: Characterization of a transgenic animal model allowing genetic manipulation of discrete populations of glutamatergic neurons  118 88 INTRODUCTION  89 MATERIALS & METHODS 91 RESULTS  95 DISCUSSION 112 CHAPTER III: Characterization of a transgenic animal model allowing genetic manipulation of discrete populations of glutamatergic neurons  118 ABSTRACT  118 INTRODUCTION  119 MATERIALS & METHODS 121 RESULTS  124 DISCUSSION 136 CONCLUSIONS AND OUTLOOK  143 118 INTRODUCTION  119 MATERIALS & METHODS 121 RESULTS  124 DISCUSSION 136 CONCLUSIONS AND OUTLOOK  143 APPENDIX I  155 BIBLIOGRAPHY  180 AKNOWLEDGMENTS  194 CURRICULUM VITAE  196

Exploring spatial diversity of neural stem cells