English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Many material properties change and become size dependent if dimensions are reduced from the micro to the nano scale. These unique, size-dependent properties of nanomaterials render them very interesting for fundamental studies and numerous applications. Nanoparticles (NPs) are a particularly interesting but challenging class of nanomaterials. Biomedical applications of superparamagnetic iron oxide NPs for therapeutic and diagnostic purposes require NPs to be stable under physiologic conditions. This can only be achieved if NPs are sterically stabilized with appropriate dispersants that bind irreversibly to the iron oxide surface. Tight control over the dispersant layer not only prevents NP agglomeration but additionally paves the way to tailor the NP size, charge and the type and density of functionalities presented at the NP surface. These factors are especially important for the in vivo performance of NPs, in particular the circulation time, targeting ability and clearance route. With the extremely high surface : volume ratio, surface functionalization becomes a key issue in the endeavor to better understand NP structure-function and structure-toxicity relationship and to explore their unique properties for applications in areas such as material science, biology and medicine. A particularly important aspect related to surface properties is the need for reliable and cost-effective approaches to stabilize and disperse single NPs. Only then can their unique, size-dependent properties be explored, controlled and utilized. One possibility to appropriately modify NP surfaces is to graft low molecular weight dispersants to these surfaces. Such dispersants typically consist of an anchor which is covalently linked to a spacer. Stabilization of NPs with low molecular weight dispersants relies on high affinity anchors that firmly bind spacers and functionalities to the NP surface at high density. Nevertheless, systematic studies comparing the performance of anchors to graft molecules to magnetite (Fe3O4) NPs are missing. Therefore, iron oxide NPs stabilized with low molecular weight are often reported to agglomerate under physiological conditions [1].

Surface modification of superparamagnetic iron oxide nanoparticles: Surface functionalizing superparamagnetic iron oxide nanoparticles using nitrocatechol anchors