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Fumihiro Ishida, Hiroyuki Ogata1), Seiichi Furuta and Kenichi Furihata1) The Second Department of Internal Medicine, Shinshu University School of Medicine 1) Department of Transfusion Medicine, Shinshu University School of Medicine A platelet alloantigen system, BraBrb, is defined recently and is implicated in several cases of neonatal alloimmune thrombocytopenic purpura (NATP) in Europe. Since each platelet has only 1,000-2,000 molecules of BraBrb antigens, it is very hard to phenotype platelets by methods in which whole platelets are used as antigens. In this study, we employed modified antigen-capture ELISA (MACE) to phenotype platelets for Br'/Br". Platelets were easily phenotyped qualitatively and semiquantitatively by MACE in which a murine monoclonal anti-glycoprotein (GP) IIa (4B4; CD29) was used to capture GP Ia-IIa complex. Phenotypic frequencies of Bra and Brb among 67 Japanese were 11.7% and over 98.3%, respectively. Their frequencies among Japanese were significantly differed from those among Caucasians and chilean Indians. BraBrb antigen system would be responsible for some cases of NATP and platelet transfusion refractoriness in Japan. MACE would be extremely useful to identify Bra/Br) incompatibility in those cases.

Phenotypic frequencies of Bra and Brb among Japanese determined by modified antigen-capture ELISA (MACE).