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A case of severe auto-immune hemolytic anemia after a living, ABO-incompatible renal transplantation is reported.The recipient, a 34 years old man, blood group A1, Rh0 (D) positive receieved a renal transplant from father whose blood group O, Rh0(D) positive donor. Cyclosporine, prednisolone and mizoribine were used for immunosuppresion.The recipient devloped severe immune hemolytic anemia within 2 weeks of renal transplantation. The recipient's serum contained anti-A1 IgG autoantibody and anti-B IgG antibody on day 18 post-transplantation. The IgG subclass of these antibodies was IgG3.

A case of immune hemolytic anemia due to "auto" anti-A1 antibody induced by group O homograft in renal transplantation recipient.