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antineoplastic therapy-associated febrile neutropenia and gram-positive bacteremia. J Chemother 2000;12:326-31. 11) Svetitsky S, Leibovici L, Paul M. Comparative efficacy and safety of vancomycin versus teicoplanin: systematic review and meta-analysis. Antimicrob Agents Chemother 2009;53:4069-79. 12) Cavalcanti AB, Goncalves AR, Almeida CS, et al . Teicoplanin versus vancomycin for proven or suspected infection. Cochrane Database Syst Rev 2010;(6):CD007022. 13) Ito H, Shime N, Kosaka T. Pharmacokinetics of glycopeptide antibiotics in children. J Infect Chemother 2013;19:352-5. 14) Fu J, Ye X, Chen C, et al. The efficacy and safety of l inezol id and glycopept ides in the treatment of Staphylococcus aureus infections. PLoS One 2013;8:e58240. 15) Kaplan SL, Afghani B, Lopez P, et al. Linezolid for the treatment of methicillin-resistant Staphylococcus aureus infections in children. Pediatr Infect Dis J 2003;22(9 Suppl):S178-85. 16) Paul M, Kariv G, Goldberg E, et al. Importance of appropriate empirical antibiotic therapy for methicillin-resistant Staphylococcus aureus bacteraemia. J Antimicrob Chemother 2010;65:2658-65. 17) Gómez J, García-Vázquez E, Baños R, et al. Predictors of morta l i ty in pat ients with methic i l l in -res istant Staphylococcus aureus (MRSA) bacteraemia: the role of empiric antibiotic therapy. Eur J Clin Microbiol Infect Dis 2007;26:239-45. 18) Shime N, Kosaka T, Fujita N. The importance of a judicious and early empiric choice of antimicrobial for methicillin-resistant Staphylococcus aureus bacteraemia. Eur J Clin Microbiol Infect Dis 2010;29:1475-9. 19) Frymoyer A, Guglielmo BJ, Wilson SD, et al. Impact of a hospitalwide increase in empiric pediatric vancomycin dosing on initial trough concentrations. Pharmacotherapy 2011;31:871-6. 20) Frymoyer A, Hersh AL, Benet LZ, et al. Current recommended dosing of vancomycin for children with invasive methicillin-resistant Staphylococcus aureus infections is inadequate. Pediatr Infect Dis J 2009;28:398-402. 21) Eiland LS, English TM, Eiland EH 3rd. Assessment of vancomycin dosing and subsequent serum concentrations in pediatric patients. Ann Pharmacother 2011;45:582-9.

Pharmacokinetics-guided vancomycin therapy in pediatric intensive care patients is like trying archery with rodeo