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Environmental  and  genetic  factors  may  play  a  major  role  in  the  development  of  nonalcoholic  fatty  liver  disease  (NAFLD)  among  people  with  obesity  and  type  2  diabetes  mellitus.  Based  on  the  fact  that  PGC-1α,  as  the  protein  encoded  by  the  PPARGC1A gene, plays a key role in energy metabolism pathways, it has been hypothesized that polymorphisms within the PPARGC1Agene  may  be  associated  with  increased  risks  of  NAFLD.  Thus,  this  study  was  designed  to  evaluate  the  Gly482Ser  polymorphism  (rs8192678) within the PPARGC1A gene and its association with the increased risk of NAFLD in Iranian patients with type 2 diabetes.

turkish journal of medical sciences

Association between PPARGC1A single nucleotide polymorphisms and increased risk of nonalcoholic fatty liver disease among Iranian patients with type 2 diabetes mellitus