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After  allogeneic  hematopoietic  stem  cell  transplantation  (allo-HSCT),  donor  natural  killer  (NK)  cells  trigger   alloreactions  against  potential  recipient  cells  by  their  killer  immunoglobulin-like  receptors  (KIRs).  This  study  investigated  whether   KIR/HLA genotypes and KIR haplotypes of donors and recipients exhibit a critical function in the prevalence of acute graft-versus-host  disease (aGVHD) and persistence of the graft after HLA-identical sibling allo-HSCT for patients with hematological malignancies.

turkish journal of medical sciences

The impact of donor and recipient KIR genes and KIR ligands on the occurrence of acute graft-versus-host disease and graft survival after HLA-identical sibling hematopoietic stem cell transplantation