Open AccessAssociation study of CTLA-4 +49A/G gene polymorphism with recurrentpregnancy loss in the Iranian Azeri Turkish ethnic group
Author(s) -
Mortaza Bonyadi,
Sara Parsa,
Simin Taghavi,
Narges Zeinalzadeh
Publication year - 2017
Publication title -
turkish journal of medical sciences
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.277
H-Index - 27
eISSN - 1303-6165
pISSN - 1300-0144
DOI - 10.3906/sag-1511-67
Subject(s) - medicine , pregnancy , ctla 4 , genotype , allele , ethnic group , turkish , immunology , polymorphism (computer science) , gastroenterology , gene , genetics , immune system , t cell , biology , linguistics , philosophy , sociology , anthropology
Recurrent pregnancy loss (RPL) is defined as two or more pregnancy losses. T-regulatory cells play an important role in the feto-maternal interface. Cytotoxic-T-lymphocyte antigen-4 (CTLA-4) is a molecule that downregulates the activation and proliferation of T cells. The objective of the current study was to investigate the possible association of CTLA-4+49A/G gene polymorphism with RPL among patients from the Iranian Azeri Turkish ethnic group.
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